Wenxin Granule Combined with Metoprolol in the Treatment of Coronary Heart Disease with Ventricular Arrhythmias:A Meta-analysis
Authors: LU Jie,LIU Chenyi,LI Jiting,LU Jianqi
Guangxi University of Chinese Medicine The First Affiliated Hospital of Guangxi University of Chines
Objective To evaluate the clinical efficacy and safety of Wenxin granule combined with metoprolol in the treatment of coronary heart disease with ventricular arrhythmia.
We searched the Pud Med, Cochrane library, China Biology Medicine disc (CBMdisc) , Chinese VIP database, Wanfang database and CNKI database (CNKI) , and collected the clinical randomized controlled trials (RCT) before August 2017 on the intervention of Wenxin Granule combined with metoprolol in treatment of coronary heart disease with ventricular arrhythmia. The data were screened by two researchers independently according to inclusion and exclusion criteria, using the software Revman 5.3 for meta-analysis. Results A total of 31 RCTs (3075 cases) were included. The total clinical efficiency, the efficiency of ECG, ST segment depression, ST segment duration, ventricular premature beat number, nonsustained ventricular tachycardia array, the incidence rate of adverse reaction in Wenxin grnule group were significantly better than those in the control group (P <0.05) .
Combined therapy method
Take wenxin keli one packet one time and thrice a day. Take
Metoprolol(6.25-50mg/time) 1-3 times a day.
The clinical effect of Wenxin granule combined with metoprolol is more significant than that of Metoprolol alone in the treatment of coronary heart disease with ventricular arrhythmia.