State-Sanctioned TCM Antiarrhythmic
Clinical Evidence
Wenxin Keli is not merely a "heart" supplement — it addresses cardiovascular health through multiple pathways.
Notoginseng isolated from saponins of Panax notoginseng had effects on cardiac electrophysiological properties and ventricular fibrillation threshold (VFT) in open-chest dogs. The cardiac electrophysiological effects were similar to those of amiodarone.
Notoginseng helps increase the effect of calcium pump on the membrane of sarcoplasmic reticulum, decrease the myocardial intracellular Ca2+, and reduce the mass of the left ventricular muscle, improving ventricular remodeling.
Ginsenoside-Rd inhibited cell proliferation and reversed basilar artery remodeling, while Rb1 and Rg1 increased endothelial-dependent vessel dilatation through activation of NO by modulating the PI3K/Akt/eNOS pathway.
Notoginseng is a good source of lead compounds for novel antiplatelet and anticoagulant therapeutics. Notoginsengnosides (NG) could inhibit both the platelet aggregation of platelet rich plasma and washed platelet after ADP induction.
Codonopsis and Rhizom polygonati nourish qi and Yin. The polysaccharide in Codonopsis increases thymus and spleen indices, boosts SOD, glutathione peroxidase and nitric oxide synthase activities, while decreasing MDA and lipofuscin.
Both Amber and Spikenard calm the central nervous system. Amber also has diuretic, scattered stasis and hemostatic effects.
Peer-Reviewed Research
Studies and clinical trials published on U.S. National Library of Medicine, Cardiology, Hindawi, Heart Rhythm, and ClinicalTrials.gov to evaluate the efficacy and safety of Wenxin Keli.
Five Traditional Herbs
Chinese herbal medicine Wenxin Keli is made of 5 herbs: Radix Codonopsis, Rhizoma Polygonati, Panax Notoginseng, Amber, and Spikenard.
The best selling #4 herbs medicine for Cardiovascular in 2023.
